Adding a NUTRACEUTICAL

A recent publication caught my eye where a study was done with mouse models of and human patients with prostate cancer.
In the mouse models, the addition of white button mushroom (WBM) extract to the diet resulted in reduction in the number of myeloid-derived suppressor cells (MDSC) which promoted antitumor immune responses mediated by T cells and natural killer (NK) cells.  They also observed increased anticancer activity of PD-1 antibodies
In patients a decline was observed in the circulating MDSCs and increase in cytotoxic CD8+ T and NK cells.  The City of Hope is recruiting for a phase 2 trial to further examine the effect of WBM on prostate cancer.
MDSCs are also  emerging target for bladder cancer.   They contribute to the ability of tumors to evade immune detection.  More research, such as that being pursied for prostate cancer, is needed to demonstrate the effect of reducing MDSCs in bladder cancer patients - however, the mechanism is the same for both.
White button mushrooms offer a number of health benefits  (including gut biome health and glucose control which I have mentioned elsewhere are of interest to me) and WBM extract is available as a supplement.
My single treatment for muscle invasive bladder cancer at the moment is pembrolizumab - an immune checkpoint inhibitor.  I've discussed with my oncologist and I am going to taking a daily dose of WBM extract to potentially enhance its effect.  I will start with dose recommended on the product I ordered (500 mg - roughly 1/4 teaspoon daily). I may adjust as I learn more of the dose used in clinical trials.  As always, with any change in diet or medication, you should consult with your care team.